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Some of these cases had neither pre-existing liver disease nor serious underlying medical condition, and some of these cases developed within the first week of treatment. Post-marketing Experience Adverse drug reactions that have been identified during post-approval use of SPORANOX kauf sporanox all formulations are listed in the table below. Antineoplastics SPORANOX may inhibit the metabolism of busulfan, docetaxel, and vinca alkaloids. Continued SPORANOX use or reinstitution of treatment with SPORANOX is strongly discouraged unless there is serious or life-threatening situation where the expected benefit exceeds the risk. Do not start using new medication without telling your doctor. If there is no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 100-mg increments to maximum of 400 mg daily. Avoid medicines for your stomach like antacids, anticholinergics and acid blockers for at least two hours after taking this medicine.