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Do not change your dose or stop NEXIUM without talking to your doctor. After administering the granules, the nasogastric tube should be flushed with additional water. There are no adequate and well controlled studies of NEXIUM use in pregnancy. Your symptoms may get better before your treatment is completed. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Mix the esomeprazole ostaa medicine with the applesauce and swallow immediately.